AI News, Weight-gain receptor linked to antipsychotic drugs, report researchers

Weight-gain receptor linked to antipsychotic drugs, report researchers

'Atypical antipsychotics are essential medications for millions of schizophrenia patients worldwide and they are increasingly being prescribed for bipolar disorder, major depressive disorder, and autism,' said Dr. Chen Liu, an Assistant Professor of Internal Medicine and Neuroscience and co-corresponding author of today's Journal of Clinical Investigation study along with Dr. Joel Elmquist, Director of the Division of Hypothalamic Research and a Professor of Internal Medicine, Pharmacology, and Psychiatry.

'Similar to treatment in humans, mice given olanzapine showed significant weight gain, higher food intake, and metabolic changes associated with insulin resistance and diabetes,' said Dr. Caleb Lord, lead author of the study and a former postdoctoral researcher in the Division of Hypothalamic Research.

Although the antipsychotic's usual effects on food intake, weight gain, and blood sugar were significantly blunted in mice lacking the serotonin 2c receptor, physical activity and energy expenditure remained lower despite the lack of that receptor.

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