AI News, Research helps explain why androgen-deprivation therapy doesn't work for many prostate cancers

Research helps explain why androgen-deprivation therapy doesn't work for many prostate cancers

'Androgen-deprivation therapy is commonly used to treat patients whose prostate cancer has spread beyond the prostate.

We have discovered a mechanism that causes progression to this aggressive form of prostate cancer, providing a new opportunity to prevent or treat lethal forms of prostate cancer,' says co-senior author David Goodrich, PhD, Professor of Oncology in the Department of Pharmacology and Therapeutics at Roswell Park.

'Importantly, these findings offer a new understanding of prostate cancer lineage plasticity, which involves the conversion of cancer cells that are dependent on a specific therapeutic target to cancer cells that are now indifferent to that target's function,' adds co-senior author Leigh Ellis, PhD, Assistant Professor of Oncology in the Department of Pharmacology and Therapeutics.

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