AI News, Improving clinical trials with machine learning

Improving clinical trials with machine learning

To test the concept, the research team looked at large-scale data from patients with stroke, extracting the complex anatomical pattern of brain damage caused by the stroke in each patient, creating in the process the largest collection of anatomically registered images of stroke ever assembled.

As an index of the impact of stroke, they used gaze direction, objectively measured from the eyes as seen on head CT scans upon hospital admission, and from MRI scans typically done 1-3 days later.

For example, given a drug treatment that shrinks a brain lesion by 70%, they tested for a significant effect using conventional (low-dimensional) statistical tests as well as by using high-dimensional machine learning methods.

With conventional low-dimensional models, the intervention would need to shrink the lesion by 78.4% of its volume for the effect to be detected in a trial more often than not, while the high-dimensional model would more than likely detect an effect when the lesion was shrunk by only 55%.

'Conventional statistical models will miss an effect even if the drug typically reduces the size of the lesion by half, or more, simply because the complexity of the brain's functional anatomy -- when left unaccounted for -- introduces so much individual variability in measured clinical outcomes.


ARE YOU READY FOR TRANSFORMATION OF YOUR LIFE ? LOOK NO FURTHER ! DHYAANGURU is a Humanitarian, Philanthropist, Mentor, Motivator, ...

Is A Brain Dead Person Actually Dead?

There are many conditions that can affect consciousness, but none as devastating as brain death. What happens to the body when brain dead? Can You Live ...

Old World Blues 14: Arguing with a Brain - Plus, Confronting the Think Tank & All Possible Endings

Subscribe!: Support on Patreon: Get an Oxhorn T-shirt:

The most important lesson from 83,000 brain scans | Daniel Amen | TEDxOrangeCoast

Never miss a talk! SUBSCRIBE to the TEDx channel: In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events ..

Yesenia A. - Traumatic Brain Injury Core/Balance

This video features Yesenia (traumatic brain injury) working on her core/balance using the Fit Assist at pressing on neuro fitness in san antonio texas.

Brain Tumor Surgery: Surgical removal of glioblastoma (GBM)

Video clip of surgical resection of brain tumor, glioblastoma multiforme. View through the surgical microscope. Courtesy of Dr. Farhad Limonadi MD director of ...

Flex your cortex -- 7 secrets to turbocharge your brain | Sandra Bond Chapman, Ph.D. | TEDxBayArea

This talk was given at a local TEDx event, produced independently of the TED Conferences. Why is there a stigma associated with our brain's health? Consider ...

The Dynamic Brain: Revealing the Potential of Neuroplasticity ...

In 2017, explore the fascinating topic of #neuroplasticity at IFM's Annual Conference. Learn about the many interventions that can improve brain function and ...

MRI - How it Works, a simple explanation of a Complex Machine

Florida Personal Injury Lawyer Matt Powell explains how MRI works. Matt Powell is a personal injury attorney in Tampa Florida who ..

The effects of trauma in the brain - Steve Reid

Steve is a teacher, both professionally and by choice. He is a very good teacher, and it shows. Steve's teaching on how trauma, both severe and mild, affects our ...